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For instance, macrophages from diabetic mice have reduced macropinocytosis, and leptin-enhanced AMPK activity increased macropinocytosis As our screen was successful in identifying these pathways, we mined the results to identify additional signaling molecules important in EBOV entry. Unbound virus and drug were removed, and viral infection was visualized for EGFP expression at 24 h postinfection by fluorescence microscopy. Polymerization was inhibited by compound C. Vaccinia virus strains use distinct forms of macropinocytosis for host-cell entry. This article has been cited by other articles in PMC. An analysis of features of pathogenesis in two animal models of Ebola virus infection.

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Functional importance of the coiled-coil of the Ebola virus glycoprotein.

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Tyro3 family-mediated cell entry of Ebola and Marburg viruses. Cells were washed thoroughly and assessed for dextran uptake by flow cytometry. Regulation of vasodilator-stimulated phosphoprotein phosphorylation and interaction with Abl by protein kinase A and cell adhesion. Analysis of filovirus entry into Vero E6 cells, using inhibitors of endocytosis, endosomal acidification, structural integrity, and cathepsin B and L activity.

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